For those of you who missed the March 29 conference call with Tom Lowe and Dr. Zach Bush on “Gut Health and Bacterial Communication,” we have the links to the audio below.  The full transcript will be available soon.

For practitioners interested in ordering wholesale, contact and mention that you heard the Tom Lowe gut health talk to receive 40% off your purchase.


Gut Health and Bacterial Communication Webinar Transcript:


Tom:  Hello, everybody. This is Tom Lowe from the SOPMed Conference, and we’re excited tonight to have Dr. Zach Bush again with us on a very important topic, which is the probiotics and how that works with gut health, which is really playing into all the rest of health that occurs. We’re glad tonight to have Zach here and to explain that a little more.


Just as a little bit of a preface here, we are having the SOPMed Conference in Salt Lake City, June 16th-18th, and it’s … All of the information is at Most of you people know that already, but I thought I’d throw that out there because you know, last year was great. This year looks to be even better, and it just excites me to have such dynamic people who have such great information that you can take back and use in your clinic. This is one of these areas, which is the area of probiotics. It’s encouraging to have a guy like Zach Bush. I’ve visited him in his clinic, spent a couple of hours with him, and really got a much broader picture. Tonight, I know he’s going to share a little bit of that broader picture with you that will allow you to take this back and use some really important information on the area of gut health and probiotics. Zach+, I’ll turn that over to you, and we’ll go from there.


Dr. Bush:  Wonderful. Thank you, Tom. Appreciate the introduction there, and we look forward to being at SOPMed this year. It was a fantastic conference that you put on last year, and we’re very excited to be putting on a full day seminar on redox chemistry, biochemistry, and cell biology and looking at the different environments and compartments of the body that make the redox molecules. We’ll have a whole day seminar. Not just with me, but Tom gave me permission to kind of put together the dream team on this one, so we’ve got members who’ll be talking about mitochondrial redox biochemistry with Gary Samuelson. Then hydrogen redox chemistry from Tyler and his team at Then we’ve got Robert Slovak who will be there speaking on water structure and its relationship to inflammation.


A really strong team of scientists from around the country speaking, and I’ll be bringing the clinical correlations and caveats that we practice every day in relation to those different modalities. Many of you are using some sort of oxidative therapy in your clinic whether it’s intravenous vitamin C or oral allyl acetic acid or whatever it is, whether you’re aware of its role or not, you’re practicing some form of it as an integrative doctor, so excited to bring more depth and breadth to that knowledge base at SOPMed.


We’re going to touch on one of those elements tonight as Tom had mentioned, and that element has to do with bacteria and their communication and relationship to the human immune system. Historically, as you know, you probably participated in the integrative health environment much earlier than I was. I was very behind the times of the historic move from the viewpoint that all bacteria are bad to this moment where we started to think that probiotics may play an important role in health and that, in fact, maybe there’s such a thing as good bacteria out there.


It’s an interesting topic that I think I short-circuited into the experience because I was not using probiotics widely in my clinic. I was an endocrinology and metabolism physician at the University of Virginia around the time I started to make my paradigm shift discoveries. That was when, for the first time, I started to think outside the human cell, if you will. I was studying cancer and mechanisms of tumor genesis and programmed apoptosis, or cell suicide, in cancer cells in my cell biology lab. I was practicing endocrinology seeing a lot of diabetes, autoimmune disease, thyroid disease, Type 1 diabetes, and a lot of metabolic disruption with high cholesterol, hypertension, cardiovascular disease and the like. Seeing what looked like two different worlds, and those started to collide when I started to realize that the diabetic ulcer on a patient’s ankle was actually a very similar process to the tumorigenesis and the development of cancer.


In both cases you have an increasingly acidic environment where there’s a breakdown in cell-cell communication and chronic inflammation building. You ultimately lose the ability to turn on the innate mechanisms of cell repair that exist in every single cell of the body. Once your cells start to lose track of their own injury rate and are no longer mobilizing cell repair, you quickly lead to a situation where you get rapid aging in that cell population. That can happen locally in the case of a peripheral neuropathy in a diabetic. You’re losing blood supply with that anoxic type environment. You’re building acidity very quickly, and you can lead to break down in tissue very quickly.


In contrast, for a cancer cell, you’re looking at many decades of unrepaired injuries that are accumulating in the cell population. Most of our models right now in cancer are showing that there’s at least 10,000-20,000 unrepaired injuries at the gene level before you get a cancer cell. An amazing amount of injury accumulating over time to result in these end stage diseases that are starting to become profoundly prevalent in our population.


If you haven’t seen the recent statistics coming out, we’re looking at 1 in 2 American adults, 49%, manifesting some sort of cancer being diagnosed before they die. And that’s, diagnosed, so you can imagine with the knowledge you have of the undiagnosed cancers out there, 70% of males now thought to have prostate cancer by the time they’re 70, and things like that. So diagnosed cancer before death, 49% now. 1 in 2 Americans looking at that, and likely, if we are able to continue to improve our surveillance methodologies in Western medicine, we’re going to find that the numbers are actually much closer to 70-80% of patients are developing a cancer somewhere in their body before they pass away, so a daunting situation.


Tom, you want to jump in there?


Tom:  Well, I think it’s one of those areas where we just don’t know where to go. I’ve researched and looked a lot. My son has a brain tumor, as you know. It’s fueled my interest in the area of cancer, and I have, I won’t say traveled the world, but everywhere from Japan to the Ukraine to Mexico and listened to people who have talked about this. In general, we just don’t know where to go. We have a few things we can do, and we’re a little better than chemotherapy. And you know, it’s just a whole wide open area where, you know, I’m looking a little bit towards you Zach, and especially the dream team coming in and giving us a some more input in here that is solid stuff that that we can really use. It’s personal to everybody. Everybody knows somebody who’s got cancer. This alternative world is really an area that we want to see more solid data and information that can really help us. I defer back to you. Take off from there.


Dr. Bush:  Yeah, I think that’s perfect. Nobody goes untouched when the prevalence ratio is 1:2. You’ve either got an immediate family member, or a distant family member, or a close friend that’s suffering from cancer right now. The rates are astonishing, you know with Tom’s situation with his son, increasingly we’re seeing very youthful patients developing these cancers. Which means, unfortunately, that the population is being born old at the biologic level. We are actually being born with our defenses down and an accumulation of injury at the cell level in utero and in those first couple years of life that have never really been seen before. Our children are developing cancers that we historically did not see at young ages, but we’re seeing children under the age of 2 developing it. You have small kids and teens developing a whole host of a vast variety of solid tissue tumors that we really didn’t see in children previously. It is a very disappointing situation.


My research was in chemotherapy, so I was very much in the mindset that you got to kill the cancer cells. You got to introduce some toxin that’s going to stress that cell out. The interesting fact though is that cancer cells are the weakest cell in the body, so we’ve got that situation going. It was in 2008, 2010 that UCLA and UCSD started coming out with publications that said, if you have breast cancer then your gut is going to show this population of bacteria. They were starting to draw a link between the gut bacteria and what type of cancer was going to be manifested. At the time, as a cancer researcher, that was like somebody saying, you know, the rings of Saturn are going to predict the cancer rate in your patient. It just didn’t make sense at all, and, you know, it would only come out of Southern California that such wacky stuff would have come out of such a tree-hugger environment.


Fast-forward a few years, we suddenly now know, oh my gosh, these bacteria are regulating a vast number of cellular mechanisms of repair, or the lack thereof, in the human host. That’s the environment where we were 2008-2010. We were starting to crack the code saying there’s at least a correlation between gut bacteria and cancer rates. We’re going to look at that tonight very specifically and see what could possibly be the role there. What is the link between one and the other?


In 2010, my department of endocrinology was collapsing. We had lost NIH funding. We were really in the midst of the major recession that was happening. We lost NIH funding that had been present since 1969 at UVA, and the GTR seat became unfunded and all my research dried up, so I had no choice but to leave the academic environment or try to jump to some other failing endocrinology department in academia. I made a scary jump, for me at least, out of academia after being there a very long time. I was at UVA for 9 years at the University of Colorado before that, so it was a scary thing to jump into private practice and primary care again. I was practicing internal medicine and endocrinology in a nutrition clinic that I started in a very rural, tiny town in a plumbing building in 2010. In that environment of starting to be able to really have the freedom to ask some tough questions about what was happening at the cell level.


I was starting to see patients turn around their health really dramatically by going to a plant-based diet, really diversifying the nutrient loads their guts were experiencing and all this. A huge percentage of our patients, cancer patients and otherwise, were not responding to the nutritional therapy. We started asking more intense questions of what’s going on. We went into soil science and that’s where we made our big discovery. In 2012, I was flipping through a soil science article and found a molecule in there, a large carbon-backbone molecule that was looking a lot like the chemo-therapeutic agents that I had been working on before. It turned out that my chemotherapy that became most successful in my work was a Vitamin A compound.


It suddenly clicked that, oh my gosh, carrots that are growing that Vitamin A compound chemotherapy probably got that nutrient or that molecular structure from the soil itself. My first thought was, “Wow, we just discovered an important breakthrough in cancer, perhaps, by looking at this molecular form.” The next question was “How did it get in the soil?” Because it’s a large carbon molecule with multiple rings and all of its cluster of oxygen and hydrogen binding sites clustered on one end of it. It even crossed my mind, “I wonder if the soil specimen they’re showing me is actually a contaminant, you know, from a hospital wash-off or something into the soil.”


It turns out that that molecule as being made by bacteria, and that was the ah-ha moment. My research had been in the mitochondrial mechanisms of communication.  Mitochondria are the organelle in the body that actually turns on cell suicide, ultimately.  The mitochondria perforates inside the human cells and triggers dependent cascades and the nucleus starts to fall apart into little bubbles and then slowly the whole cell, over a 72 hour period turns into something that looks like bubble tea or something like that and dissolves and disappears. That process of apoptosis is triggered by mitochondria.


If you think about what mitochondria are, those only occur in eukaryotic cells. The multi-cellular eukaryotic organism of an inchworm or a drosophila or a human, all of those are eukaryotic cells that are completely dependent on the mitochondria for even the simplest mechanisms of cell metabolism and fuel production. In the human case, like the inchworm or like the drosophila or fruit fly, we’re fully dependent on those mitochondria to take the food we eat and turn it into usable ATP for the human cell effort.


That’s the eukaryotic world. If you know anything about mitochondrial redox, which I’m sure most of you do with the industry you’re in, you’ll remember that the mitochondria make about 15 variants of oxygen-hydrogen compounds that we call redox molecules-reduction and oxidation molecules. Those redox molecules coming out of the mitochondria is really the foundation of intracellular communication and cell repair.


It was therefore, not that hard of a leap, mentally, for me to look at this compound that clearly had redox potential with all of these oxygen-hydrogen binding sites and realize it’s being made by bacteria to realize, oh my gosh, we’re missing like the biggest piece of the biologic communication network in our current biologic model in cancer or otherwise. We forgot about the bacteria. Never have we studied cancer in anything but a sterile environment, and that’s been our big downfall, I believe, is we missed the boat on the role of bacteria and their impact on the communication network that sets up the environment for cancer.


The bacteria, as you know, is a prokaryote. It’s a single-celled organism. No mitochondria in a prokaryote. There’s no organelles in a prokaryotic cell, so it made sense completely all of a sudden that oh my gosh, the bacteria have to make their own communication network because they have no mitochondria to do it. And of course it would have to be a redox molecule because it requires, not only intracellular communication, but in a bacterial environment, it requires species to species communication. That cross-species communication network that would allow for a balanced ecosystem of bowel bacteria would have to be dependent on a communication network.


That’s frankly never even been discussed in the literature to any significant degree. Really exciting to think that oh my gosh, the communication is being produced much like it would in the mitochondria of the eukaryote. The prokaryotic cells are building their whole own language network. The interesting thing when you start going down this route is to realize that, wow, each species of bacteria can make its own little packet of vocabulary. Each mitochondria is capable of making around 15 different redox molecules out of the respiratory chain in the wall of the mitochondria there, the electron transport chain or respiratory chain. With those 15 different words, if you will, if you see each redox molecule as a word, you can start to see each species could be responsible for their own little packet of a dozen or so words. If you have a complex ecosystem of 20,000 or 30,000 species like we expect to see in a really healthy human organism, suddenly you’ve got this huge vocabulary with probably over a million different words.


That fluid communication, we believe, is the most important cancer breakthrough that we’re ever going to stumble upon in our careers, but more importantly for humans, it’s probably the most important breakthrough we’ll make regarding our most acute problem right now, which is a drastic dilemma in gut health.


Go ahead, Tom.


Tom:  And this is one of the areas that we see, I want to take a probiotic, I’ve got some problems, so I throw in, what, 5 to 15 different species? There’s billions of them going in and I’m trying this, you know, and I go, well where does this lead us then? Because 5, 10, 15 different species really are not going to give us that communication that we need to really, you know, work with this gut health that is going to work with our overall health. I think that was real revelatory to me as I listened to some of the things, and I know you’re going to expound on that right now. You know, as I send out the email, what’s wrong with probiotics? Why isn’t that working? Why isn’t that giving us what we need? That kind of leads into where we’re going to go now, I’m sure, with what you’re thinking.


Dr. Bush:   That’s perfect. It’s perfect.  You just described kind of a truncated or very abbreviated vocabulary that we would be adding with a probiotic, so I hope that if you’re listening to us on the phone to the conversation anew, you’re starting to realize that we need to stop thinking about bacteria as a single concept and start thinking about this as an ecosystem. Like Tom mentioned, your probiotic that you’ve been using clinically may have up to 24 species. There’s a couple of new ones on the market that bragged had maybe 100 species, whether or not that’s true is a whole other thing.


Let’s assume that best case scenario, you can get 100 species. If you have 100 species and you’re taking 35-50 billion copies of each of those species on a daily basis, you’re overwhelming the gut ecosystem with a mono-culture. That’s the dilemma that we have in our food chain. That’s the dilemma that we have in our soil system. We have mono-culture going everywhere. Now, as clinicians we’re actually repeating that with this probiotic message. I believe that probiotics can have a reset effect on the gut. So, just exposed to chemotherapy or exposed to viral infection of the gut, or exposed to an antibiotic course, you may have some purpose to throwing some probiotics on there for a couple of weeks to try to check the growth of the weed-like organisms that can crop up. E. Coli, klebsiella, pseudomonas, candida, the like, but you’re nowhere near getting at a balanced ecosystem by having your patient take probiotics long-term. In our clinic, we’ve really over the last 5 years, adopted the practice where we don’t use probiotics long-term ever.


As many of you know, there are huge drawbacks to our probiotics that go beyond this discussion such that the vast majority of probiotics on the market don’t even use bacteria that typically colonize the human gut. We are growing most of the cultures for our probiotics from the intestines of bovine or cows. Those organisms typically cannot colonize the human gut, and instead, those 35 billion copies or 50 billion copies are building this temporary environment on a daily basis every time you take that capsule. That temporary environment throws everything off and then as soon as it showed up, it’s starting to disappear leaving in its void the opportunity for those weed-like organisms to crop back up. I believe this is why a lot of patients have found themselves relatively dependent on probiotics because as soon as they stop, they feel worse, they get more IBS, they have more symptoms of small bowel overgrowth. Not necessarily because the probiotics wasn’t helping them, but because you’ve just left a void behind it and the weeds that are going to crop back up are those invasive species.


Probiotics, I think, at best are short-term band-aid, never a solution. They’re never really getting at a diverse ecosystem even if you’re looking at it just as a bacterial thing. Then as Tom says, if you start to appreciate the importance of cell-cell communication and the possibility that oh my gosh, I wonder if each species is making its own system of carbon-based redox communication, we may have a much bigger story behind the importance of biodiversity and ecodiversity.


That’s what we have in the product Restore. We started with that realization that bacteria speak. We knew we needed to go after a source that had a vocabulary that probably didn’t exist in common day soils. At best, we’re in a situation where even our best organic farms are looking at between 12 inches and 3 feet of top soil. Typical farms much less than that. Or your back yard, you’re looking at only a couple of inches of topsoil in most situations. In can take a lot of work to get anything looking like a balanced or complex ecosystem in the soil these days. If we look back in time, the story is much, much different.


We went back in time 50 million years by simply going A. to a desert where the sedimentary rate is quite slow in the desert compared to a very verdant space like we have here in Virginia. The southwest United States was a good spot where just a couple feet underground, you can find fossil layers of soil that are 50 million years old, and that’s what we’re tapping into. That layer of ore is called lignite. You can imagine this as a young coal. If you left this compressed under the Earth for another 50 million years, it would turn into a black coal. But right now it’s kind of halfway between the humus layer of rich soil and black coal. Kind of a tannish brown layer of fossil soil.


From that we’re extracting not the bacteria because those are long dead. It’s a sterile process, and we’re not even going after the minerals. There’s been a lot of other products on the market over the years that are soil extracts. There’s fulvic acids, humic acids, there’s shilajit and the like. All of those products are going after mineral context. We are far less in for the minerals. In fact, we are very aware and have demonstrated in our own labs and university labs that high mineral content and fulvic acids and stuff are actually kidney toxic. Instead of going after those potentially oxidative mineral sources, we’re going after these carbon molecules. All of our raw materials from that soil are inert. They don’t do anything to cancer cells. They don’t do anything to healthy cells. It’s a very passive raw material.


We bring that raw material back out to Virginia here, and in our own labs here, we have produced every bottle of Restore. That process is getting the oxygen-hydrogen binding sites on these carbon-based molecules to start to communicate again. We used an entirely soil based system to extract from the main raw ingredients, and then we use soil extract catalysts to get the oxygen-hydrogen binding sites. Everything in our product is entirely soil-based and every raw ingredient is sourced out of the United States for quality control.


So incredibly safe product, we’ve got gold standard renal tubule studies showing that we have the highest level of safety really ever reported in a product. You can take this up to 100% concentrations on renal tubule cells and show no increased cell death or toxicity. In fact, we extend cell life by as much as 15% in those renal tubule cells, so that’s a definite improvement in longevity of renal tubule cell in vitro that hasn’t been seen since the 1960s. Really exciting breakthroughs in cellular health and cell repair even in the toxicity trials that we did.


Going past that then, the next mechanism was to see what it did in cancer, and it had all the predictable properties of a redox communication network in cancer cells. If you start to realize in that human environment where the mitochondria are the intracellular repair system and mechanism of communication, and the bacteria are providing the extracellular communication network. That was something that I hadn’t even wrapped my mind around until we did our cancer studies, and what we saw there is something amazing. In vitro breast cancer cells, both from MTF7 cell lines, which are the typical ones used in pharmaceutical trials. The problem with MTF7 is that they are long immortalized cell lines that have more similarity to fibroblasts than they do to actual breast cancer cells. Nonetheless, the pharmaceutical industry uses that as kind of their gold standard.


We’ve gone beyond that and we’ve actually pulled breast cancer cells out of our own patients and gotten those in a culture, immortalized those cell lines through a non-genomic pathway so that we’re leaving them in their native state and then test in those environments as well and we see the same things. Breast cancer, colon cancer, prostate cancer, bladder cancer cell lines as well. Vast array of tests that we’ve done and in each one when you add the Restore you see a differential response in your cancer cell versus your healthy cell population.


This differential response has never been seen in any other therapy that is on the market.


If you take vitamin C, hydrogen peroxide, ozone, alpha-lipoic acid, ASEA, any of these, ASEA is the mitochondrial redox supplement. You take that, it does the exact same thing across the board in cancer cells versus healthy cells. It rapidly up-regulates reactive oxygen species out of the mitochondria and all cell types and then you hope you get apoptosis of the cancer cells. In contrast, Restore, as that extracellular communication network and seems to have that ability to turn on and off cells between the two populations deferentially.


In the case of the cancer cell it up-regulates reactive oxygen species and turns on apoptosis very quickly, whereas in the healthy cell population it down-regulates reactive oxygen species, thus reducing stress on the healthy cell population. You have this beautiful differential response showing that this is the very first compound or family of molecules that we’ve ever had that seems to be able to sense, at the cell surface, what to tell the cell to do: up-regulate or down-regulate raw, depending on the damage state of the cell.


That kind of gives you an idea of how effective this huge communication network is once you get these hundreds of thousands of species involved. We believe that’s what we are seeing. With 50-million-year old soil, that fossil layer that has been compressed for 50 million years is still eight feet thick. Imagine the layer of humus or topsoil that existed 50 million years ago that would have compressed over those millennia to still be eight feet thick. We must have had 100 feet of topsoil on the planet back then, so really intriguing to imaging that ecosystem and how diverse and beautiful it was. We’re extracting that intelligence, that level of vocabulary out of that soil and putting that in the human gut now with Restore.


That’s why, I think, why we see magic happening every week. Not because Restore is fixing anybody’s disease, it’s simply putting all the communication network into play again so that every cell can go about doing what it does best, which is cell repair. My patients on my hospice service who die at 105 years old, every single cell in their body has all the machinery to do cell repair and in the event that the cell is damaged beyond its ability to repair, it can induce apoptosis and then a stem cell gets called in to replace that cell.


We have all of this machinery sitting idle in 105-year-old who passes away from failure to thrive and just deconditioning. That patient could be biologically 20 years old and has all the mechanisms to be young and healthy, that machinery is just sitting still. You put the communication network back in play and the cells go into their innate process of sorting out who’s healthy, who’s not, who needs repair, who needs replacement, and the rest.


Tom: This has to do, too, with the variety, I take it, of bacteria that is going to be, I won’t say created, but you’re going to stimulate this diversity in the gut with Restore. It’s not just the carbon molecules that you’re putting in but it is actually the restoration of the bacteria? Am I reading that right, Zach, from what I’ve listened to?


Dr. Bush:   You’re spot on. You’re spot on, and it’s an interesting process that we didn’t expect at all. I had a pretty good hunch as to what we had, as far as the carbon redox system and extracellular communication network. I had no idea it was going to have this effect on tight junctions like we’re going to show you in a minute. I had no idea it was going to have this effect on the bacterial proliferation that you’re describing there.


The first patient that we put this on was a 59-year-old woman with two years of pancreatic cancer who was given a week to live when she was discharged from the hospital after a quick ER visit. She was down to 59 pounds, full bowel obstruction from her huge pancreatic tumor that was compressing her duodenum. She hadn’t eaten a meal in almost four months. You could see her entire anatomy through her skin. You could see her gall bladder on the side of her liver. You could see her spleen. It was just an extraordinary exam to see someone this emaciated. And yet … She was having what we call chalk stools, or white chalk stools. She had so little organic material left in the gut that really all she was passing was the epithelial lining of the intestines every few days. She was passing these little white chalk-looking stools.


She started on our product and within four days had her first large bowel movement that was brown and rich. That, I was not expecting and it took me quite a while to figure out how that had happened that quickly. In the end, it looked like we are able to repopulate our gut if we get that carbon substrate back in the gut. You can almost picture Restore being the healthy compost to create the soil that will support that bacterial life again. It’s a really nice positive feedback loop. You put Restore in, which is a sterile product, you get the communication network backup, every breath the patient takes she’s going to breathe in bacteria from her pet cat, from her dog, from her garden, from the neighbor walking in and giving her a hug. Everybody is introducing bacteria to her environment every day and when you get back that compost, it’s all able to get a foothold again and you can very quickly rebuild the system.


I’m going to jump now and I’m going to show you the relationship of that communication network to your front line of defense. You’ve been looking at this picture here. We’re going to show you a picture here of a video. This is a time-lapse video that we’re doing in our clinic. It’s an extraordinary picture that you’re going to see here. This is 16 minutes of raw data under the microscope. This is in an immunohistochemistry environment. Immunohistochemistry is going to tag the tight junctions between the epithelium of the gut lining green. You’re going to see a green glow between the cells. On the left you’re going to see the introduction of glyphosate, which is the active ingredient in Round-Up, and on the right you’re going to see Restore with the communication network from the bacteria plus the glyphosate simultaneously.


With glyphosate on the left we’re going to start at 0 minutes and then we’re going to fast-forward it in time-lapse fashion every two minutes. We’re going to take you to 2 minutes, 4 minutes, on out to 16 minutes. On the left you have your treatment with 10 parts per million glyphosate. This is the amount of Round-Up that you would expect to see on a beet at the grocery store. EPA says 10 parts per million is a very safe amount and so you’re going to see at 6 minutes you can now see on your screen a slight decrement on the tight junction. At 10 minutes it becomes quite obvious that you’re dimming and developing clear breaks. By 16 minutes you have almost complete dissolution of the tight junctions between the system.


Over the same 16 minutes you’re actually seeing up-regulation of the tight junction expression under the influence of Restore that was introduced at the same time as the glyphosate. In real time, you can see the decimation that can happen when your patient with a vulnerable gut develops this. This is now closing the loop on, how does the loss of bacteria in the gut lead to a complete breakdown of the immune system and the accumulation of cancer in the body? We think that this tight junction story is probably one of the most likely sources of this.


Adam, you can replay that video one more time for us.


Adam: Sure.


Dr. Bush:  We’ll let people watch that one more time. As you’re looking at this now, what I’m drawing for you now is the relationship between your immune system and the bacteria. Your immune system, 70% of it or so, sits in the GALT, the Gastrointestinal Associated Lymphatic Tissue. The GALT is sitting right behind the epithelial lining of your small and large intestines and your nasal sinuses. If you think of every breath you take, every drink you take, every bite of food you take, the first place that it’s going to hit the system is the tight junctions. If your tight junction network is up and strong, it never hits your immune system to create an immune response.


If you’ve got glyphosate, if you’ve got Round-Up in there, which is now in every single bite of food we eat, if it’s present you’re going to see this decrement in tight junction function and you’re going to start to get leak. With that leaky phenomenon, even if you don’t have the classic features of leaky gut that you’re familiar with in your clinic, the patient start to develop leak, not just at the gut membrane, but in every blood vessel of the body, the blood-brain barrier, the kidney tubules, the injury goes wide-spread.


Multiple structures are being damaged across these membranes and we’re losing integrity. That reality, I think, is what you’re going to see as a clinician. Closing the loop on your understanding of how do you see changes happen so fast in your patients? If you’re treating autistic children or someone who has a really compromised gut, you’re going to see really wildly crazy clinical results in three days with just five drops of the product under this patient’s tongue. It can take tiny amounts in an autistic child to see massive results and the reasons have a lot to do with this relationship between the bacteria, the production of communication, and the relationship of that communication and tight junctions and their maintenance.


You start to lose bacteria, you start to lose the communication networks, you lose your front line of defense, and suddenly every breath you take, every bite you take becomes noxious to the greater system. Chronic inflammation is inevitable. The host is now aging at a much more rapid rate than previous generations because of this constant insult of the herbicides and pesticides that we have on our plants. That’s a lot of material to cover in a short amount of time, from the spectrum, but I think it gives you a foundation to start to shift your viewpoint on the probiotic situation that we have. That’s a 30-billion-dollar industry that’s built on very little science in the end. Let’s go ahead and open that up to communication.


I know a lot of you have a lot of clinical experience with probiotics and a lot of questions I’m sure as to why you’ve seen improvements or you’re starting to see why you haven’t seen improvements, or patients improved briefly and then decline again, etc. We’re going to open that up.


Dr. Bush:  We’re going to first do bottle giveaway. We’re giving one away now and in an hour we’ll give away a case to listeners so stay tuned. Daria Davison has won 1 bottle of Restore. Daria, if you can email your mailing address to, we’ll send you a bottle out. Adam, if you would like … If you could do the poll question now.


Adam: Sure. Poll question for everyone on the line, and you can just press the number on your phone keypad to respond. The question is what percentage of your patients do you prescribe probiotics to? What percentage of your patients? If it’s less than 25% of your patients, just press 1. If you’d say it’s between 25 and 50%, press 2. Between 50 and 75%, press 3. Over 75%, press 4. Go ahead and do that now. Again, the question is what percentage of your patients do you prescribe probiotics to? Less than 25%, press 1, 25-50%, press 2, 50-75%, press 3, above 75%, press 4.


All right. Thank you for those of you who have responded. It looks like the majority of you are prescribing less than 25% and then several from 25-50%, and just a couple above that. Thank you.


Dr. Bush:  We’re going to open it up to questions now. If you have a question you can press 1 on your keypad and we will call on you. All right. Elizabeth, you are live. Ask your question.


Elizabeth: Thank you. I am Elizabeth King. I work with detoxing and cleansing in my clinic and the gut health is what I actually specialize in. I’m very excited to be on this program and I do give all of my patients probiotics because we work with colon hydrotherapy and cleaning out the gut and reestablishing a good flora in the gut, but always used probiotics for that. I currently use a strain that has 40 different species in it and 150 billion, but from what I’m seeing here now, that’s almost negligent. Would love to know where to get your product from and would you suggest that I use it on my patients when they’ve done a detox program, and we want to reset and regenerate and rejuvenate the gut? Thank you.


Dr. Bush:  Perfect, sounds like you have an exciting clinic. Big fan of that colon therapy and aggressive efforts to change that colon biology. We have used it extensively in a variety of ways that would be pertinent to your practice. Number 1, I think that you’re right on track now that you’re see that while you’re reaching for the best products that you can in a probiotic industry, the industry is still reaching out with pretty poor options for you.


One thought, if you really feel like you do need a probiotic source, there is a new company that is out of Australia that, they’re having a hard time breaking into the US market because they can’t reach clinicians, and the doctors are really the only ones that are going to understand their product, but it’s only a two strain probiotic. It’s made by a Gastroenterologist down in Australia. It is the very first product on the market that is actually cultured from human intestines. They have two of the most common healthy bacteria that colonize the human gut and do a great job. That product is called Progurt, like yogurt but instead of yo- it’s P-R-O. Progurt is the product down there. A little hard to find and order, but if you can get it I would say that would be the only probiotic that I would use with any regularity in a colonics clinic.


I think that once you start to work with Restore, you’ll realize that you probably don’t need that source, because once the compost is there the person is going to get a vast number of bacterial species from their environment, their immediate family members, etc. I think you’re going to be able to back off your probiotic use and put the efforts into Restore.


Elizabeth: I would love that. I would love that if you could tell me where to get it.


Dr. Bush:  Where are you practicing?


Elizabeth: In Utah, Salt Lake City.


Dr. Bush:  The easiest way to do it is jump on our website and click on info@restore4life and that’ll get you to our customer service. Or you can click on “start a wholesale account” is another tab on the website. The website is Our wholesale account manager can get your clinic set up with your own wholesale account there as one method for getting it to your patients.


Elizabeth: I would love that. Sir, can you just answer one quick question for me? I always end off my detox program with a liver flush, removing the stones out of the pancreas, gall bladder, liver, and kidneys. Would it then be very important that I go rather onto Restore, rather than a probiotic straight after that before they end.


Dr. Bush:  I would actually lead and follow with Restore. One of the issues with doing a detox like that is when you have a big bile dump like you do with the treatment you’re using there, as you know, bile is one of the main mechanisms by which the liver dumps toxin. When the liver processes toxin, its then excreted in the bile and is now passed in the gut. The problem is most of your patients have profoundly leaky gut. So, you may be dumping it from the liver but you’re putting it right back into the small intestines where, leaky gut environment, you’re absorbing those same toxins within minutes or hours and they’re going to have to go through the whole process again. I believe that’s why people are stuck in this cycle of “I have to do a detox every few months”, because they keep absorbing a significant amount of the toxin that they’re trying to secrete.


In contrast, if you put the patient on a couple days or a couple weeks of Restore before the cleanse, their tight junctions are going to be up-regulated. They’re going to have a much better front line of defense, so when you do the big liver squeeze, all that bile is going to pass through the small intestine without inappropriate absorption. Lead with Restore. I don’t see any harm in doing the cleanse as you do it, and then you’re going to follow and keep them on Restore throughout the process. That would be one mechanism.


The other thing I want to mention before you’ve gone off and we’ve moved to another question is you can use this thing rectally, and so Restore is a liquid that is easy to apply through a small volume enema and I would highly recommend doing that after every colonic. You’re going to have a much quicker re-population of that colon environment without getting the weeds crop up. With colonics you’ve got an opportunity there and you’re going to take full advantage of the opportunity if you can get that gut really bathed from above and below with the Restore.


David: All right, Mary-Ellen, you are live. Ask your question.


Mary-Ellen: Hello, can you hear me?


Dr. Bush:  Yes, thank you.


Mary-Ellen: Yes, I just saw a new patient yesterday with atrophic gastritis.


Dr. Bush:  Were they on chronic antacids?


Mary Ellen: No, this all came about after … Found out about it after having an MI a couple years ago and he kept having symptoms as if he was having another MI, and when they went in to do an endoscopy they found atrophic gastritis. We’re not sure about …


Dr. Bush:  I would definitely go to his medication list. It’s so typical for patients after a heart attack to be thrown on a proton-pump inhibitor. That’s the most common reason for atrophic gastritis to occur. Number 1, check the med list. Make sure there’s not a proton-pump inhibitor like Pantoprazole or Omeprazole or one of those, and stop that medication if they are on it.


Atrophic gastritis is a good example of where there was initial insult, usually from pharmacy. It may have happened through acute exposure to the aspirin and the statin drugs he was thrown on when he had the heart attack. It could have been a pharmaceutical insult, but when the atrophic gastritis happens, you get an under-acidification of the rest of the gut. The stomach is no longer producing adequate amount of acid. When the stomach dumps its contents into the duodenum, you’re no longer getting that big PH drop which then encourages the bile to dump and your digestive enzymes to secrete from the liver and pancreas. Without that, then you’re prone to small bowel overgrowth and it turns into a vicious cycle there. Key to atrophic gastritis is A, get the communication network back up and running, so we use Restore as the frontline. Restore has a very direct anti-inflammatory effect at the mitochondrial level, as we mentioned, so all the healthy cells will down-regulate ROSS, and the damaged cells will up-regulate the reactive oxygen species and call for cell repair and replacement if needed.


First of all, start with that. You’ll have a nice clinical effect in the rate at which he’s going to have these chest pain episodes will reduce pretty quickly as the inflammation settles down, as his tight junction network goes back up. And then you’re going to get a nice secondary response with increased acidification. In atrophic gastritis I almost always will augment with hydrochloric acid. Start HCL with betaine or HCL with pepsin as a short-term therapy for 2-3 months, while you’ve got the patient on Restore.


Mary-Ellen: So the Restore will help heal that whole stomach area?


Dr. Bush:  The cool thing is that Restore doesn’t heal anything. The body heals it. The extraordinary reality is that Restore is actually just the communication network that’s going to turn the normal mechanisms of cell repair back on. By taking the stress off … When it reduces reactive oxygen species throughout the whole healthy population of the body, it functionally increases the antioxidant reservoir, etc, so that the areas of damage that may be existing, not only in his stomach lining, but in his heart muscle and his peripheral tissues and his joints, his osteoarthritis, all of the issues that he has. All of those areas you’re now have more reservoir for doing what they do best which is just cell repair and replacement.


It’s a challenge, but it’s an important one that I’d say you want to keep doing as you understand and learn Restore, is stop thinking of it as a therapy for anything and start thinking it about as the foundation for normal cell repair.


Mary-Ellen: Okay. So he is having episodes of chest pain and he would go in to see his cardiologist and they’d do more arteriograms and put in more stents.


Dr. Bush:  Yep, that’s unfortunately a very common scenario. Unfortunately, I think that’s the majority of chest pain centers is non-cardiac chest pain. I was at UVA for many years and spent a long time, a lot of hours in the emergency room running the chest pain center and I can certainly attest to the fact that the vast majority of chest pain is not coming from the heart.


David: All right. If you have questions, please press number 1 on your touch pad. We will now take a question from Joanne. Joanne, you are live.


Joanne: I have to say that I’ve been using the Restore now for 8 months in my clinic as a colon hydro-therapist and I’ve taken all my clients off of probiotics, digestive enzymes, and they are experiencing huge, huge progress. I’m talking about vegans that have been eating organic, that time after time I would do colon cleanses and undigested food would be coming out. It’d be fermented. It would be full of mucous, and that’s all gone away now. So thank you, so much.


Dr. Bush:  I pretty much didn’t need to talk. I should have just had you come on for 10 minutes at the beginning and we’d be done. Thank you for summarizing that in a very short amount of time.


Joanne: The problem is that I’m seeing candida coming out of everybody, including 13, 14, 15-year-old children now, and even that has started to diminish. I was using large amounts of probiotics, digestive enzymes, and so on and so forth for the last 6 years and to no avail. There was no progress being made. And now, my goodness gracious, they’re calling me off and saying, “My mom’s got this, can she go on it? My Dad needs this”. I’m seeing … I’ve never, ever had a product in my office where I’ve had so many people come back say, “I need 3 bottles because my brother and my sister need this.” I can’t thank you enough.


Dr. Bush:  I can’t thank you enough for getting the word out there. There’s very few things that’s more frustrating than having an amazing breakthrough in science and watching it get out slowly. Fortunately, this thing has been getting out so fast and furious, we’ve been growing vertically since out debut a year and a half ago. We are growing at 760% …


Joanne: I’ve been with you every step of the way.


Dr. Bush:  You sure have.


Joanne: And I am going to be seeing you in SOPMed and despite my fear of heights I’m going to be there and I’m waiting for the dream team. I can’t wait. Thank you Dr. Bush.


T Dr. Bush:  hank you for your hard work out there. Keep up the great work.


Joanne: Well not a problem, hon.


Dr. Bush:  Circling back to that, she mentioned that she’s seeing younger and younger people with candida and I think that it’s important to realize why. It’s probably a part of your clinical history taking that you’re doing, but you’ll remember not to miss it in the future. If you have someone coming in chronic fatigue, chronic fibromyalgia, chronic major depression, chronic degenerative conditions, autoimmune disease, first question should always be: Where were you born? How were you born? And in what birth order were you born?


As you know we’re looking at our rates of C-section now in the United States that are reaching close to 50%. With that many children being born via sterile C-section, we’re no longer passing on the healthy ecosystem of vaginal flora that sets up life for the child. Babies are now born sterile, pulled out of the belly through a sterile incision and then placed on the hospital environment. They’re inheriting not mom’s flora, but the bacteria of the hospital. That’s a devastating situation. That’s why, at such a young age we’re seeing children manifest huge ecosystem imbalance. That’s why they’re presenting with chronic rhinitis, chronic allergies, food sensitivities, and the like. They were born without a frontline of defense. They were born with a very truncated communication network in the bacterial biome and they, at very young ages, will manifest candida and other things that we used to associate with elderly diabetics and the like. Really fascinating relationship to the change in our birth environment and our health outcomes there.


David: Great, thank you, Dr. Bush. We’re going to give … Before we wrap it up we’re going to give away a case of Restore. Thanks everyone for joining us tonight. The case of Restore goes to Robert Banner. Robert, if you can email with your mailing address, we will get that out to you. Tom?


Tom: It’s been really another interesting time. Every time Zach speaks I’m a little bit set back because I want to listen more and more, and I think that’s what happened last year at the conference. I had people say, “It was worth the whole cost of the conference just to listen to what Zach was going through”, and we’ve got more than one Zach coming in this year … Dr. Bush, which is great with Chris Shade coming in, Robert Slovak, Gerry Tenant, and of course Gary Gordon is going to be there. It’s just another powerhouse thing.


My goal is good information to the doctors that they can take home and use on Monday when they get back. You’ve participated in that; you’re going to give us more of that. It just is an encouraging time for me to be a part of this whole thing. What a blessing God has given me to be able to be a part of your work, Dr. Zach Bush, and all the doctors that are going to come. I feel very privileged. I just want to encourage everyone to spread the word that it’s going to be another great conference and just kind of go from there. I thank you again for another enlightening evening that gives us more confidence in what we can do and how we can do it to help patients. Thanks a lot, Zach, and David, and all you that are participating tonight.


Dr. Bush:  I would just echo all that. I think Joanne is a good example of why it’s important for us to get together as a community of providers. Ultimately, we have a public health crisis that’s never occurred in human history. We have rates of cancer, autism, etc. that have just never been seen before, and it’s exciting, I agree, to be in this moment where science is finally catching up with reality and we’re starting to get real answers to the problems we have. Without the communication and effort of the physicians on the line and practitioners … Without that effort where you guys are giving another evening of your time to try to further your own education … It’s just a real encouragement that there is a public health revolution going on. It’s non-pharmaceutical. It is really a re-connection to our nature and our power to win the game for our kids and grandkids. We appreciate your participation tonight, look forward to seeing you at the SOPMed and other ATIM events and goodnight. Thanks, Tom, appreciate it.


Tom:  Thank you much, Zach, and we will see you soon, I’m sure. To all of you out there, blessings on you, and I trust you got what you came for and more. Thanks much, Zach and David and good night.